Abstract by Jeremy Tsang
Chemistry and Biochemistry
Capillary Morphogenesis gene 2 mediates multiple pathways of growth factor-induced angiogenesis by regulating endothelial cell chemotaxis
Pathological angiogenesis is linked with diseases like cancer and serious eye disorders, but it lacks efficacious therapies. Identifying new anti-angiogenic targets is critical for new therapeutic development. Here, we report that one of the anthrax toxin receptors, Capillary Morphogenesis Gene 2 (CMG2), plays an important role in mediating angiogenesis. Competitive inhibition of CMG2 binding to its physiological ligands results in a significant reduction of pathological angiogenesis versus the growth factors VEGF and bFGF as observed in models of corneal neovascularization, endothelial tube formation, and endothelial cell migration. Importantly, we recently discovered that CMG2 likely mediates angiogenesis by regulating endothelial cell chemotaxis. CMG2 knockout (KO) endothelial cells showed dramatically decreased chemotaxis when compared to wild type (WT) cells. Together, CMG2 has been identified as a promising target for new therapeutic development that targets pathological angiogenesis against multiple grow factors by arresting endothelial chemotaxis.