Abstract by Concordia Lo
Chemistry and Biochemistry
Microwave Promoted Iminyl Radical Fragmentations for the Synthesis of Functionalized Nitriles
A variety of functionalized nitriles are synthesized by microwave promoted fragmentations of cyclic O-phenyl oxime ethers. Different radical traps were utilized to generate diverse products containing C-O, C-C, C-N, or C-X bonds. Notable advantages of this method include short reaction times, compatibility with 5 membered rings, and absence of metal catalysts or toxic initiators. The application of this procedure was demonstrated by the ring-distortion of estrone.