Abstract by Darius Baradaran
Chemistry and Biochemistry
Antifungal activity of ceragenin-containing formulations in an ex vivo model
In this study, we evaluated the efficacy of different gel and cream formulations of CSA-44 and CSA-131 in an ex vivo mucosal tissue model infected with C. albicans or clinical isolates of C. auris and compared them to commercial antifungal drugs including Nystatin and Monistat. CSA formulations were comparable and in some cases more effective against fungal infection than these commercial drugs. In tissues infected with C. albicans and C. auris Nystatin showed a log reduction of 1.4 and 1.0 respectively; however, gel formulations of 2% CSA-44 and CSA-131 caused 4.6 and 5.3 log reduction of C. albicans and reduction of comparable amounts of C. auris. Moreover, Monistat 7 and CSA-44 reduced fungal counts by 1 log and 4 logs respectively in the tissues infected by C. albicans. Both formulations were less effective against C. auris, with Monistat 7 not causing a significant reduction in fungal counts and CSA-44 leading to a 1 log reduction.