Abstract by Camille Jackson
Chemistry and Biochemistry
Using Glycerol as a Reducing Agent for N-Oxides
In this study, glycerol acts as a reducing agent in a molybdenum catalyzed reduction of pyridine N-oxides. Pyridine is a common base in organic reactions but is often protected by an oxygen. Traditional methods to deprotect the pyridine N-oxides require stoichiometric amounts of metals, high temperatures, and overall harsh conditions. Glycerol is an abundant waste product from biofuel production, and due to its abundance and low toxicity, interest in finding a use for glycerol has increased in recent years. Using glycerol as the reducing agent allows for a green system with milder conditions than previously used. We are able to achieve conversion using 10% catalyst at lower temperatures than traditional deoxygenation reactions. The effectiveness of glycerol as a reducing agent was tested using various solvents, molybdenum catalysts, times, scales, and temperatures. We have found that the glycerol successfully performs the deoxygenation, but there is an interaction between the product and the catalyst that requires further research.