Abstract by Max Jones

Personal Infomation

Presenter's Name

Max Jones



Degree Level



Monique Speirs
Connor Holman
John Price

Abstract Infomation


Chemistry and Biochemistry

Faculty Advisor

John Price


Applying proteomics and metabolomics to understand the role of sphingolipid signaling in pancreatic cancer and drug sensitivity


Cancer cells often alter metabolism in response to external stressors, such as anaerobic conditions, nutrient deprivation, and chemotherapy in order to survive. Our studies have focused on altered cell-fate sphingolipid signaling in pancreatic cancer, and the proteins involved. Our results indicate that pancreatic cancer cells upregulate proteins associated with proliferative signaling relative to healthy phenotypes to increase their viability and chemoresistance. We are using isotopic labeling, proteomics, and lipidomics in order to understand how protein expression affects the metabolism of sphingolipid-mediated growth signals and how protein expression changes as cells gain chemoresitance. By tracking isotopically labeled substrates and proteins we will better understand the regulation of proliferative pathways, and ultimately identify drug targets of sphingolipid signaling.