Abstract by Stephen Harris

Personal Infomation

Presenter's Name

Stephen Harris

Degree Level


Abstract Infomation


Chemistry and Biochemistry

Faculty Advisor

Richard Watt


The Role of TIMPs in Fibrosis


Liver fibrogenesis is a process that operates through complex mechanisms that are not completely understood. Historically, much research has been done in the area of Matrix Metalloproteinases, but recent research points rather both in the direction of the direct inhibitors of Matrix Metalloproteinases, known as TIMPS, as well as fibrogenic hepatic stellate cells (HSCs). The chemotaxial nature of the HSCs is suspected to be a key factor in the propagation of fibrosis as well as the spread of TIMPs throughout the damaged system. Using protein docking programs, proteins and drugs may be identified which may inhibit the activity of these TIMPs. Investigating these methods may allow normal reconstructive measures to resume in the system and possibly provide a means to hinder the progress of or even reverse fibrosis in many patients.