Abstract by Kyle Gassaway
Chemistry and Biochemistry
Exploring the Abilities of a Boron-Templated Cascade Reaction
We have discovered a new boron templated cascade reaction which cyclizes allylic alcohols without expensive, toxic metal catalysts. This product can be easily hydrolyzed to give a diol product seen in natural products such as wutaienin. Upon optimization and examining the substrates tolerated by the reaction, we found that the reaction gave good to moderate yields for varying aromatic allylic alcohols. Current research focuses on an enantioselective approach using a chiral boron compound.