Abstract by Jeffrey Coombs
Chemistry and Biochemistry
Quantitative Measurement of Blood Insulin with Surface-Enhanced Raman Spectroscopy
Type II diabetes or insulin resistant diabetes is becoming increasingly common. This condition is most commonly diagnosed through detection of elevated fasting blood glucose. A much earlier diagnosis could be made by measuring blood insulin. Insulin levels increase years before blood glucose begins to rise. However, high cost and requirement of trained personnel inhibits measurement of blood insulin becoming a common test.
Surface-enhanced Raman spectroscopy (SERS) has shown promise in detecting and quantifying proteins in complex biological matrices. Our aim is the development of a cheap, reproducible SERS substrate to measure blood insulin. A simpler method of measuring insulin will make the test more common, which will lead to earlier diagnosis and better outcomes for patients.