Abstract by Jessie Payne

Personal Infomation

Presenter's Name

Jessie Payne

Degree Level



Eddie Lee
Jeremy Tsang

Abstract Infomation


Chemistry and Biochemistry

Faculty Advisor

Kenneth Christensen


CMG2 in Angiogenesis


Angiogenesis, the formation of new blood vessels, plays a pathological role in many diseases such as cancer and corneal neovascularization.  Anti-angiogenic therapies are therefore of interest in the treatment of these and other diseases. Capillary Morphogenesis Gene 2 (CMG2) is a transmembrane cellular receptor that is shown to be upregulated in angiogenesis; in addition, inhibition of CMG2 leads to decreased angiogenesis in vivo.  Our lab has discovered that two crucial steps in angiogenesis- cellular adhesion and chemotactic migration across the extracellular matrix- can be significantly decreased upon competitive inhibition of CMG2. In addition, CMG2 KO cells showed limited ability to respond to migrate toward a serum gradient.  All of this points to CMG2 as a key player in the angiogenic process, and one that could be targeted in potential anti-angiogenic therapies.