Abstract by Nathan Lyons
Chemistry and Biochemistry
Boron-Templated Dimerization of Alkenes and Hydrolysis
We have been interested in using metal catalysts to simplify complex procedures and boost the yield of key pharmaceutical reactions. Our most recent discovery is that cinnamyl alcohol reacts with phenyl boronic acid, copper (II) triflate as a catalyst, and PPh3 as a ligand, forming an addition of allyl and hydroxyl groups across the double bond. This bond is typically difficult to form and signifies a significant advancement in synthesis of complex molecules. The optimization of this reaction will bridge the gap between simple molecules and complex pharmaceutical compounds. Hypothesis: That this reaction can be useful to the community by making complex medicinal compounds cheaper and more available to common individuals.