Abstract by Ethan Damron
Chemistry and Biochemistry
Copper (II) N-(-2-aminoethyl)glycine and its Adamantane Analogs as Influenza Inhibitors
Influenza is a highly infectious viral disease that affects hundreds of thousands of people globally each year. Traditional influenza drugs target the M2 proton channel, which is found in nearly all strains of the influenza A virus, to inhibit viral activation. However, numerous mutations to the M2 channel has caused common influenza A drugs, such as amantadine and rimantadine, to become ineffective. Copper complexes show promise as potential influenza A drugs because copper binds tightly to the imidazole groups in the His37 tetrad in the M2 proton channel, which is conserved in nearly all influenza A virions. In this study we investigate copper (II) N-(-2-aminoethyl)glycine (Cu-AEG) and its adamantane analogs as potential influenza A drugs. We determined that the CC50 of our compound is 15.5 µM, which is comparable to amantadine (16.0 µM). Additionally, our tests determined that our copper complex showed a 7% block of the M2 proton channel, which is unsatisfactory when compared to amantadine’s 93.6% block against the WT influenza A virus. We are now working to create an adamantane analog of Cu-AEG in an attempt to improve the percent block of the M2 proton channel.