Abstract by Austin Ellis
Chemistry and Biochemistry
Cell migration, the connection between Rho signaling and CMG2.
New vasculature formation is critical to various diseases such as cancer. For example, tumor development is facilitated by inducing angiogenesis to provide nutrients to the growing cancer. In the past decade, capillary morphogenesis gene 2 (CMG2) has been shown to play a role in angiogenesis. CMG2 is a highly upregulated gene in endothelial tubule formation, an important process for angiogenesis. Inhibition of CMG2 interferes with proper vasculature formation. While CMG2 is known to play a part in angiogenesis, its role is not well understood. Our lab has recently shown that CMG2-/- endothelial cells eliminate chemotactic migration towards vascular growth factors, another angiogenic process. Rho signaling is critical for cell migration and chemotaxis; however, no connection between CMG2 and Rho signaling has been reported. We report that CMG2 and Rho inhibition result in similar observed phenotypes and RhoA interacts with CMG2 to putatively regulate endothelial cell chemotaxis.