Abstract by Austin LeSueur
Chemistry and Biochemistry
Exploration of α,β-Dehydroamino Acid Synthesis Methods
Dehydroamino acids apear occasionally in nature and form interesting peptides and proteins. They have been shown to stabilize peptides to proteolysis and hold them in a more rigid conformation. Current synthesis methods for these dehydroamino acids are limited and are not easy to use after an acid is incorporated into the peptide. We are looking for better methods of dehydrating ß-hydroxy amino acids to form these dehydroaminoacids after they have been incorporated into the peptide chain. To do this, we made a model tripeptide and tested a variety of reagents to see which of them work.