Abstract by Emily Gardner
Chemistry and Biochemistry
Synergy of Antimicrobial Peptide Mimics and Amphotericin B Against Fungi
The emergence of drug-resistant pathogens raises concerns about the future efficacy of commonly used antibiotics. A significant amount of research focuses on developing new drugs or strategies for combating infection. Antimicrobial peptides, which occur naturally in the human body, show promising properties. For example, pathogens do not generally develop resistance against these peptides. Ceragenins are mimics of antimicrobial peptides but are cheaper to synthesize and are not metablized by proteases in biological environments. While ceragenins exhibit some toxicity at higher concentrations, they may exhibit synergy in combination with other drugs. Synergy describes a cooperative relationship between two or more therapeutic agents which produces a combined effect that is greater than either individually. These synergisitc effects allow drugs to be given at lower, non-toxic concentrations while still achieving the same antipathogenic effect. Studies have been conducted to determine if ceragenins show synergy with other antifungal drugs. The results of these studies may give some insight into how ceragenins may be used to combat infection.