Abstract by Stacy Allington
Chemistry and Biochemistry
Peptide Synthesis and its Effect on Dual-Catalyst Systems
Catalysts are an integral part of chemical synthesis due to their ability to promote reactivity and selectivity that would not otherwise be achievable. The Michelis lab has created a peptide scaffold to induce proximity between catalysts in a dual-catalyst system. The objective of this project is to create enzyme-like reactivity and selectivity that can lead to improved drug synthesis and new reaction pathways. Our hypothesis is that by placing two catalysts in close proximity on a helical peptide scaffold, we can achieve faster reaction rates and new multi-catalyst systems. For example, on locations “i+4” and “i+7” amino acids on the helical peptide scaffold we can target specific side chain groups and attach a catalyst to them. These new bifunctional peptides will then react with each other and react with a substrate creating enzyme-like reactions. Currently we are synthesizing a bis-glutamate peptide and a disymmetric salen ligand which we will couple to the carboxylic acid function end of the glutamic acid residues. We hope that this will yield even faster reaction rates for asymmetric ring opening of meso epoxides.