Abstract by Trevor Godfrey
Chemistry and Biochemistry
The Effect of Gold Nanoparticles on Inflammatory and Metabolic Pathways
Gold compounds have been used as medicines since the early 1900s, Tuberculosis being one of the first conditions treated with gold. Today gold molecules are used to treat autoimmune diseases (such as rheumatoid arthritis), suppress parasitic infections, and aid in wound healing. The safety profiles of most gold medicines show only very mild side effects that generally resolve themselves without intervention. Studies with the arthritis gold drug auranofin showed antioxidant properties and anti-inflammatory properties such as blocking the inflammatory pathway IL-6/Jak/Stat3 to lower inflammation. Gold molecules stimulate the activation of antibodies suggesting they modulate the immune system. Recent work has shown that gold nanoparticles alter the NAD / NADH balance in the cell in a favorable way to stimulate important metabolic pathways that show potent neuroprotective effects. I will report how gold inhibits inflammatory pathways and activates metabolic pathways to promote health.