BYU

Abstract by Collin G. Cribbs

Personal Infomation


Presenter's Name

Collin G. Cribbs

Degree Level

Undergraduate

Co-Authors

Jonard Corpuz Valdoz
Miranda T. Sudo

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Pam Van Ry

Title

Mining the cancer databases to create a metastasis biosensor

Abstract

Current technological advances allowed for the diverse available datasets for several diseases. These initiatives allow researchers to access datasets remotely. Though vast information is available, converting them into functional therapeutic for diseases is still limited. We view this lack of available therapy for certain diseases especially cancer metastasis to be due to low-throughput drug screens. Here, we identified a central biosensor for metastasis. We initially mined TCGA and CGC for lung carcinoma having an overlap of ~23,000 genes. With our efforts, we were able to narrow down these reporter genes to 1 gene. We then created a stable reporter cell line which has potential for high-throughput screening of drugs against metastatic cancers.