BYU

Abstract by Spencer Taylor

Personal Infomation


Presenter's Name

Spencer Taylor

Degree Level

Undergraduate

Co-Authors

Merritt Andrus
Isaac Smith

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Merritt Andrus

Title

Chiral and achiral acetamide synthesis and reactivity

Abstract

Nocardioazine A is a natural product that shows promise in anti-cancer therapies. It can only be harvested in small amounts from algae or synthesized in a lengthy process.  An important intermediate in a total synthesis of Nocardioazine A is an acetamide that comes in a chiral and an achiral form. This acetamide intermediate also shows promise as an important molecule in other organic reactions. One of class of reactions that this acetamide intermediate can undergo are radical alkylation using Lewis acids or photocatalysts and visible light. The new chemical pathways based of the chiral and achiral acetamide intermediates and the work towards a simpler total synthesis of Nocardioazine A would lead to new synthesis methods and clinical applications of Nocardiozine A in anticancer therapies.