BYU

Abstract by Jonard Corpuz Valdoz

Personal Infomation


Presenter's Name

Jonard Corpuz Valdoz

Degree Level

Doctorate

Co-Authors

Connor J. Knight
Nicholas A. Franks
Pam Marie Van Ry

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Pam Van Ry

Title

Novel Bioengineered Models for the Human Lung: Angiogenesis, Fibrosis, and Cancer Metastasis

Abstract

Metastasis is the major cause of cancer-related deaths worldwide. It is mechanistically known to be driven by epithelial-to-mesenchymal transition (EMT). Though biochemically mapped, metastatic cancers still do not have effective therapeutics, thus, considered as terminal illnesses. A major culprit to this problem is the lack of effective organ mimics for cancer. Here, we bio-engineered a lung model for cancer metastasis. Our model uses a novel suspension system which the author developed. This method expedites (~14 days) organ formation unlike traditional systems (>60 days). Our model also features ability for cell-lineage tracking—epithelial, mesenchymal and endothelial—which is crucial in the study of cancer progression, metastasis and vascularization. Altogether, our model provides an expedited way to study cancer metastasis in the level of an organ which will be necessary in the understanding of the process and the development of patient-specific therapeutics