BYU

Abstract by Joseph Chanthakhoun

Personal Infomation


Presenter's Name

Joseph Chanthakhoun

Degree Level

Undergraduate

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Steven Castle

Title

Synthesis of Bulky Alpha,Beta-dehydroamino acids

Abstract

Alpha,Beta-dehydroamino acids (dAAs) are dehydrated, planar analogs of amino acids shown to impart substantial proteolytic stability in peptides. Given this property, dAAs can be incorporated into peptide-based pharmaceutical drugs to potentially heighten their stability and potency. However, it is currently unknown which dAAs, whether small or bulky, are best for imparting proteolytic stability or the most efficient methods for synthesizing them. This study is a progress report on the synthesis of dehydrovaline and its precursors. By understanding the synthesis mechanisms of this dAA, methods for synthesizing other dAAs can be developed to test their incorporation into peptides.