Abstract by Cole A. Lyman
Cole A. Lyman
M. Stanley Fujimoto
Mark J. Clement
Discovering Genome Wide Association using the Polygraph
Since the advent of DNA sequencing technology, uncovering the underlying cause of genetic diseases has become a reality through Genome Wide Association Studies (GWAS). Over the past decade, many GWAS have been performed with varying degrees of effectiveness. A potential reason that some GWAS have proved ineffective is due to the relatively sparse input they take in, namely single nucleotide polymorphisms. Our work introduces a GWAS method that utilizes the entire genome sequence as input, with the benefit of detecting more complex types of mutations than just single nucleotide polymorphisms. We illustrate the foundational methodology as well as preliminary results for an antibiotic resistance GWAS in Staphylococcus aureus.