BYU

Abstract by Maren Kenison

Personal Infomation


Presenter's Name

Maren Kenison

Degree Level

Undergraduate

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Pam Van Ry

Title

Gastroesophageal Reflux: A New Model for Idiopathic Pulmonary Fibrosis

Abstract

Idiopathic Pulmonary Fibrosis (IPF) is characterized by chronic, unknown injury to the lungs that leads to formation of fibrotic tissue causing loss of lung elasticity and eventually death. The lung fibrosis is unresolvable, and the cause is unknown. The current mouse model used for testing IPF treatment is not a perfect model as it spontaneously resolves 3 to 4 weeks after the injury event. As a result, translational therapeutic testing is usually unsuccessful. Our goal is to create an animal model for IPF that more closely mimics clinical disease manifestations. Since 90% of IPF patients have gastroesophageal reflux events, we have been testing the effects of simulated intestinal fluid with pepsin (SIFP) and gastric juice with pepsin (GF+P) on the lungs through micro aspirations in mice. We quantify the fibrotic burden using weekly micro CT scans. Fibrotic burden has increased in mice treated with SIFP making this model a promising method for IPF therapeutic testing.