Abstract by Maren Kenison
Chemistry and Biochemistry
Pam Van Ry
Gastroesophageal Reflux: A New Model for Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is characterized by chronic, unknown injury to the lungs that leads to formation of fibrotic tissue causing loss of lung elasticity and eventually death. The lung fibrosis is unresolvable, and the cause is unknown. The current mouse model used for testing IPF treatment is not a perfect model as it spontaneously resolves 3 to 4 weeks after the injury event. As a result, translational therapeutic testing is usually unsuccessful. Our goal is to create an animal model for IPF that more closely mimics clinical disease manifestations. Since 90% of IPF patients have gastroesophageal reflux events, we have been testing the effects of simulated intestinal fluid with pepsin (SIFP) and gastric juice with pepsin (GF+P) on the lungs through micro aspirations in mice. We quantify the fibrotic burden using weekly micro CT scans. Fibrotic burden has increased in mice treated with SIFP making this model a promising method for IPF therapeutic testing.