Abstract by Connor Holman
Chemistry and Biochemistry
Investigating Modified Lipid Metabolism in Brain Tissue Associated with Varying Isoforms of Apolipoprotein in Relation to Alzheimer\'s Disease
Lipid transport and metabolism are connected to multiple predictors of Alzheimer’s Disease (AD) risk. Apolipoprotein (APoE), a protein involved in lipid transport is the strongest genetic risk factor. APoE2 demonstrates a low risk for AD development, APoE3 contains neutral risk for AD development, and APoE4 is associated as a risk factor for AD development. Bioactive lipid signaling, has been associated across a variety of cell-signaling pathways and plays a key role in determining cell fate. While it has been shown that possessing the APoE4 isoform increases likeliness of AD development, the connection between APoE4 and modified lipid metabolism has not been fully explored. Using mouse brain tissue collected from the 3 APoE isoforms, I will present our recent work investigating changes in lipid transport and metabolism. This will help determine to what how lipid transport and metabolism impacts biochemical pathways within the brain to modify AD risk.