BYU

Abstract by Daniel Joaquin

Personal Infomation


Presenter's Name

Daniel Joaquin

Degree Level

Doctorate

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Steven Castle

Title

Progress Towards the Total Synthesis of Yaku\'amide A Analogues

Abstract

Yaku'amide A was first isolated from a sponge Ceratopsion sp. in the deep China sea. It has growth inhibitory profile against a panel of 39 human cancer cell lines. The total synthesis of the natural product is lenghty and complex due to E and Z isomers in the peptide backbones. Computational studies performed in our lab have identified two possible analogue candidates that have similar properties as Yaku'amide A. These analogues bypass the need for E and Z isomers, using symmetric dehydro amino acids, hence simplifying the steps in total synthesis. Hereby, I present the progress towards the total synthesis of Yaku'amide A analogues, more specifically the synthesis of the center tripeptide and left side heptapeptide.