BYU

Abstract by Brian Brown

Personal Infomation


Presenter's Name

Brian Brown

Degree Level

Undergraduate

Co-Authors

Kristi Bresciano

Abstract Infomation


Department

Computer Science

Faculty Advisor

Mark Clement

Title

Fighting Germs with Machine Learning

Abstract

Antibiotics have saved untold millions of lives since their emergence in the early 20th century. However, microbes can develop resistance to antibiotics, rendering antibiotics less effective. This potentially serious problem has been remediated by the consistent development of new classes of antibiotics over time. Unfortunately, the last few decades have seen a decline in new antibiotic discovery, and antibiotic resistance looms as a greater and greater threat. We present a new method for antibiotic discovery that leverages machine learning and high-throughput laboratory techniques to identify common themes in antibiotic substances. By training an artificial neural network to recognize toxic and non-toxic substances, our method was able to classify substances as antibiotic, neutral, or probiotic with an accuracy of 72%, or approximately two and one-fifth times better than random guessing. Our success in predicting antibiotic properties indicates common features among antibiotic substances that can be identified and exploited for future antibiotic development.