BYU

Abstract by connor yost

Personal Infomation


Presenter's Name

connor yost

Co-Presenters

Samuel Ellis

Degree Level

Undergraduate

Co-Authors

None

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Paul Savage

Title

advances towards the synthesis of SA antigen serotype 8

Abstract

Staphylococcus aureus (SA) an important human pathogen due to its virulence and increasing drug resistance.   Efforts have been made to generate vaccines to SA, and these have been based on large, partially-purified polysaccharides coupled to a protein carrier. Anti-saccharide responses to these vaccines are T-cell independent do not generate high affinity antibodies or memory responses.  Our approach to SA vaccines it so prepare smaller, synthetic glycans for attachment to nanoparticles.  We have shown that this type of vaccine results in high affinity antibodies and memory responses.  We will show the advances we have made towards the synthesis the targeted glycan for SA vaccines.