BYU

Abstract by Michael Kinghorn

Personal Infomation


Presenter's Name

Michael Kinghorn

Co-Presenters

None

Degree Level

Doctorate

Co-Authors

None

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

David Michaelis

Title

Rationally Designed Bifunctional Helical Peptides for Enzyme-like Selectivity

Abstract

Peptide secondary structures have been shown to greatly increase the efficiency and selectivity of organic catalysts.  Previous work conducted in our lab has shown that tethering two organic catalysts in close proximity on a helical peptide scaffold led to greatly increased catalytic performance as well as selectivity that was otherwise unobserved.  Herein we report the design of new befunctional helical peptides for optimization of reaction kinetics.  New catalysts were screened in order expand the reaction scope to TEMPO mediated oxidation reactions as well as selective acylation of secondary alcohols and sugars.