Abstract by Michael Kinghorn
Chemistry and Biochemistry
Rationally Designed Bifunctional Helical Peptides for Enzyme-like Selectivity
Peptide secondary structures have been shown to greatly increase the efficiency and selectivity of organic catalysts. Previous work conducted in our lab has shown that tethering two organic catalysts in close proximity on a helical peptide scaffold led to greatly increased catalytic performance as well as selectivity that was otherwise unobserved. Herein we report the design of new befunctional helical peptides for optimization of reaction kinetics. New catalysts were screened in order expand the reaction scope to TEMPO mediated oxidation reactions as well as selective acylation of secondary alcohols and sugars.