Abstract by David Schvaneveldt
Chemistry and Biochemistry
Degradation Study of Nalbuphine
Nalbuphine is an analgesic drug commonly used in hospitals to treat opioid induced pruritus following Caesarean section. Pruritus, or severe itching, is a common side effect of intrathecally-induced morphine, affecting most women undergoing Caesarean section delivery. Nalbuphine is commonly administered following the procedure, alleviating pruritus caused by the morphine while maintaining the analgesic effects. However, despite its regular use following Caesarean section deliveries, hospitals are required by law to discard compounded nalbuphine after 48 hours. The lack of stability data prevents hospitals from compounding nalbuphine in bulk, and stocking it to be readily available for patients. Hospitals will save much time and money if stability studies of nalbuphine longer than 48 hours were available. We are testing the stability of nalbuphine compounded in normal saline solution over a 14-day period when stored at 2-8 degrees Celsius.