BYU

Abstract by Logan Larsen

Personal Infomation


Presenter's Name

Logan Larsen

Co-Presenters

None

Degree Level

Undergraduate

Co-Authors

None

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Joshua Andersen

Title

The Role of TNK1 in Cancer

Abstract

Receptor tyrosine kinases (RTKs) have emerged as a family of cell surface receptors that are key regulators in important cell processes such as proliferation, motility, and survival.  Mutations and aberrant activation of their intracellular pathways have been causally linked to cancer.  Another class of tyrosine kinases, non-receptor tyrosine kinases, are cytoplasmic proteins that transduce signals to cellular organelles. Several non-receptor tyrosine kinases (e.g., ALK, BCR-ABL) are well-established oncogenes.  My study is focused on TNK1, a poorly understood non-receptor tyrosine kinase that we believe promotes oncogenic transformation.  Our preliminary data are the first to suggest a mechanism of TNK1 activation. These data suggest that TNK1 is activated downstream of platelet-derived growth factor receptor kinase (PDGFRK), which triggers binding of the protein 14-3-3z. This interaction is required for TNK1 kinase activity. What remains unknown is the kinase that directly phosphorylates TNK1 and the role of TNK1 in cell motility.