BYU

Abstract by Theo Stoddard-Bennett

Personal Infomation


Presenter's Name

Theo Stoddard-Bennett

Co-Presenters

None

Degree Level

Undergraduate

Co-Authors

None

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Richard Watt

Title

Gold Nanoparticles as Catalyst for Oxidation of NADH

Abstract

Multiple sclerosis (MS) is an inflammatory disorder that damages the myelin sheath surrounding neurons. Oligodendrocytes (OL) surround the neurons and repair the myelin sheath but inflammation prevents myelin repair. Healthy OLs use glycolysis for energy and produce lactate as a precursor for myelin synthesis but inflammation slows glycolysis. It is hypothesized that methods to stimulate glycolysis in OLs will provide a treatment for MS. Recent work showed that gold nanoparticles (AuNPs) increase glycolysis in OLs but the mechanism is unknown. We propose that AuNPs alter the NAD + /NADH ratio and shift OLs toward glycolysis for energy. We demonstrate in vitro that AuNPs oxidize NADH to NAD + using UV/Vis methods. This catalytic property may have further important biological and medical properties for inflammation.