Abstract by Steven Christiansen
Chemistry and Biochemistry
Gold nanoparticles (AuNPs) as a Potential Treatment for Demyelinated Neurons by Restoring Glycolysis in Oligodendrocytes
Inflammatory disorders and oxidative stress cause neurodegeneration, and one hallmark of neuron damage is neuron demyelination. Oligodendrocytes (OLs), a type of central nervous system glial cell, surround the neurons and repair the myelin sheath. Inflammation blocks OLs from repairing myelin. OLs predominantly use glycolysis for energy and lactate synthesis, but inflammation slows glycolysis, decreasing lactate, which is an important starting material for myelin synthesis. Stimulating glycolysis in OLs is a potential treatment for neurodegeneration. Gold nanoparticles (AuNPs) were recently shown to stimulate glycolysis in OLs by potentially altering the NAD+/NADH ratio in OLs. AuNPs with different capping agents or no capping agents were tested for their ability to oxidize NADH to NAD+. We report on the effectiveness of each of these AuNP variants for altering NAD+/NADH ratios.