Abstract by Ryan Moore
Chemistry and Biochemistry
Activity of Ceragenins in presence of Pluronic F-127 on Pathogenic Bacteria and Fungi
Given the recent emergence of a variety of drug-resistant bacteria and fungi, there is increasing concern regarding potential infections by such pathogens. Ceragenins, mimics of endogenous antimicrobial peptides (AMPs), represent a novel approach in treating such infections. The potential applications of ceragenins in treating and preventing infections are numerous and diverse, ranging from coatings on medical devices to potential treatments for persistent lung infections in patients with cystic fibrosis. There has been a concern that ceragenins may damage the cilia of the respiratory epithelium. In this study we showed that by administering ceragenins as a mixture with Pluronic F-127 (Poloxamer 407), these damaging effects can be entirely eliminated without diminishing the ceragenins’ antimicrobial potency.