BYU

Abstract by Gregory Mohl

Personal Infomation


Presenter's Name

Gregory Mohl

Co-Presenters

Joseph Nygaard

Degree Level

Undergraduate

Co-Authors

None

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

David Michaelis

Title

In Silico Discovery of Influenza Polymerase Inhibitors

Abstract

Resistance makes the influenza virus a difficult target for antiviral development. M2 blockers are ineffective against most strains due to point mutations in the M2 channel. Neuraminidase inhibitors are also vulnerable to resistance, highlighting the need for antivirals that inhibit infection by a new mechanism. Novel Influenza inhibitors were identified using a high-throughput virtual screen of a protein-protein interaction inhibitor library. Three of the compounds purchased from this library inhibited Influenza protein synthesis. Variants of the top compound were synthesized and characterized, and several compounds were identified with nanomolar inhibition of Influenza protein synthesis. Three of these derivatives protected MDCK cells against Influenza A and B in the CPE assay. Viral resistance develops slowly, suggesting that these inhibitors target a key, conserved binding site.