Abstract by Erika Weir
Chemistry and Biochemistry
Proximity-enabled dual catalysis on a bifunctional helical peptide catalyst
Our laboratory has demonstrated that multifunctional helical peptides can enable enzyme-like reactivity by scaffolding multiple catalysts in close proximity. This scaffolding effect can enable new dual catalytic processes by catalytically generating two reactive intermediates in close proximity on the peptide scaffold. In this report, we will describe our efforts to develop new dual catalytic processes that take advantage of the helical scaffold to enable proximity-driven reactivity and selectivity.