Abstract by Chloe Ence
Chemistry and Biochemistry
Enantioselective Allylic Amination using Hetetrobimetallic Catalysis
Heterobimetallic palladium-titanium complexes generate efficient and enantioselective catalysis for the intramolecular allylic amination of hindered secondary amines. In situ catalyst generation and mild reaction conditions provide easy access to many amine products. Six phosphinoamide-titanium ligands were used as well as a variety of substrates to produce different pyrrolidine derivatives. At 5 mol % catalyst loading cyclization can be completed in four hours in up to 50 % enantioselectivity.