BYU

Abstract by Chloe Ence

Personal Infomation


Presenter's Name

Chloe Ence

Co-Presenters

None

Degree Level

Doctorate

Co-Authors

None

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

David Michaelis

Title

Enantioselective Allylic Amination using Hetetrobimetallic Catalysis

Abstract

Heterobimetallic palladium-titanium complexes generate efficient and enantioselective catalysis for the intramolecular allylic amination of hindered secondary amines. In situ catalyst generation and mild reaction conditions provide easy access to many amine products. Six phosphinoamide-titanium ligands were used as well as a variety of substrates to produce different pyrrolidine derivatives. At 5 mol % catalyst loading cyclization can be completed in four hours in up to 50 % enantioselectivity.