BYU

Abstract by Jonathan Lynch

Personal Infomation


Presenter's Name

Jonathan Lynch

Co-Presenters

None

Degree Level

Doctorate

Co-Authors

Roger Harrison

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Roger Harrison

Title

Polyamine Complexes of Copper (II) for Influenza A M2 Inhibition

Abstract

Influenza A continues to be an evolving threat and active topic of research. The M2A channel, a proton pump that activates the flu’s reproductive cycle, is one avenue of research with a somewhat limited ability to evolve defenses. Most M2A studies have focused on solving the channel’s structure and learning more about its activation and pumping mechanisms. However, mechanistic studies on rules for selection and rejection for ingress of molecules into the channel have been somewhat lacking. This is especially true concerning charged metal complexes targeting the His37 residue, an absolutely-conserved site essential for channel activation. The synthesis and characterization of several polyamine copper complexes will be outlined, and their activity in the channel will be discussed. Work with these dicationic complexes will be compared to previous research on net-neutral diacetate complexes.