BYU

Abstract by Naomi Flindt

Personal Infomation


Presenter's Name

Naomi Flindt

Co-Presenters

None

Degree Level

Doctorate

Co-Authors

None

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Richard Watt

Title

Zinc Bound Metallothionein Facilitates Ferritin Loading

Abstract

Alzheimer’s Disease (AD) has elevated reactive oxygen species (ROS) and low Metallothionein
(MT). Excess Fe +2 in the cells increases ROS and cellular damage. We are testing a hypothesis
that zinc bound to MT (Zn:MT) loads free Fe 2+ into ferritin preventing ROS. Methods to
increase Zn:MT may prevent ROS and slow the progression of AD. The consumption of
polyphenols, isothiocyanates, and zinc, increase MT and glutathione (GSH) levels. We propose
increased GSH and MT will mitigate the effects of ROS by storing free iron in ferritin. Zn is
critical for folding transcription factors (Zn fingers) that bind to DNA and initiate MT and GSH
synthesis. We present data showing Zn:MT can load free iron into ferritin. We outline how Zn
can up-regulate MT and GSH expression. Maximizing iron sequestration and activation of
protective genes will enhance treatments for AD.