BYU

Abstract by David Kastner

Personal Infomation


Presenter's Name

David Kastner

Co-Presenters

None

Degree Level

Undergraduate

Co-Authors

Steven Castle

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Steven Castle

Title

Progress toward synthetically simplified Yaku’amide A analogues

Abstract

Due to the complex amino acid profile of Yaku'amide, little progress has been made in understanding its anticancer mechanism. To address this problem we designed eight yaku'amide mimicking analogues in silico and geometrically optimized them using quantum mechanic/molecular mechanic hybrid simulations. The results of the study show that two of the original eight analogues closely mimic lower energy conformations of Yaku'amide.