BYU

Abstract by Ryan Moore

Personal Infomation


Presenter's Name

Ryan Moore

Co-Presenters

None

Degree Level

Undergraduate

Co-Authors

Marjan Hashemi

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Paul Savage

Title

Activity of Ceragenins in presence of Pluronic F-127 on Pathogenic Bacteria and Fungi

Abstract

Given the recent emergence of a variety of drug-resistant bacteria and fungi, there is increasing concern regarding potential infections by such pathogens. Ceragenins, mimics of endogenous antimicrobial peptides (AMPs), represent a novel approach in treating such infections. The potential applications of ceragenins in treating and preventing infections are numerous and diverse, ranging from coatings on medical devices to potential treatments for persistent lung infections in patients with cystic fibrosis. There has been a concern that ceragenins may damage the cilia of the respiratory epithelium. In this study we showed that by administering ceragenins as a mixture with Pluronic F-127 (Poloxamer 407), these damaging effects can be entirely eliminated without diminishing the ceragenins’ antimicrobial potency.