Abstract by Michael Lee
Chemistry and Biochemistry
Substitution of Bulky Dehydroamino Acids in 310 Helices
Bulky dehydroamino acids are analogues of amino acids that have exemplified enhanced proteolytic resistance. With the rise of peptide-based pharmaceuticals, this increased resistance can provide longer-lasting, more effective medicines. Inspired by the synthesis of the Yaku’amide A, a potent cytotoxin, we have devised a target tetrapeptide to analyze the effects of dehydroamino acids against proteolysis in proteins with the 310 helix secondary structure. My presentation will outline the synthetic pathway for our desired peptide and compare possible results with previous research done on beta-hairpin peptides.