BYU

Abstract by Michael Lee

Personal Infomation


Presenter's Name

Michael Lee

Co-Presenters

None

Degree Level

Undergraduate

Co-Authors

None

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Steven Castle

Title

Substitution of Bulky Dehydroamino Acids in 310 Helices

Abstract

Bulky dehydroamino acids are analogues of amino acids that have exemplified enhanced proteolytic resistance. With the rise of peptide-based pharmaceuticals, this increased resistance can provide longer-lasting, more effective medicines. Inspired by the synthesis of the Yaku’amide A, a potent cytotoxin, we have devised a target tetrapeptide to analyze the effects of dehydroamino acids against proteolysis in proteins with the 310 helix secondary structure. My presentation will outline the synthetic pathway for our desired peptide and compare possible results with previous research done on beta-hairpin peptides.