Abstract by Stephen White
Chemistry and Biochemistry
Synthesis of Analogues of Yaku\'amide A
Yaku’amide A is a rare protein with anti-cancer properties that utilizes a unique mode of action. Because of its extreme scarcity and its lengthy synthesis, studying this unique mode of action has been difficult. To shorten the synthesis of the compound, we have designed and begun the synthesis of two simplified analogues of Yaku’amide A that we hypothesize will maintain its unique mode of action.