BYU

Abstract by Cecilia Foster

Personal Infomation


Presenter's Name

Cecilia Foster

Degree Level

Undergraduate

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Pam Van Ry

Title

Creating a New Mouse Model for Idiopathic Pulmonary Fibrosis Using Acid Reflux

Abstract

Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease resulting in
scarring of the lungs that affects 3 million people worldwide. The cause and a cure are
currently unknown, and the average life expectancy after diagnosis is only 3.8 years.
IPF is highly correlated with gastroesophageal reflux (GER), as 87% of patients
diagnosed with IPF also have chronic GER. The currently used mouse model induced
lung injury with bleomycin which only partially recapitulates IPF disease phenotypes We
hypothesize that chronic, subclinical levels of gastric juices will injure the lungs, result in
fibrosis, and will be a new mouse model that is more physiologically relevant to IPF
patients. To mimic GER, mice were aspirated with simulated intestinal fluid with active
pepsin for 7 days. Three sets of data were collected weekly for three weeks: the
mouse’s weights, treadmill distance (which correlates to the six-minute walk test of IPF
patients), and HR-μCT scans. These data will help us determine if gastric juice/pepsin
treatment can simulate IPF symptoms in mice.