BYU

Abstract by Andy Bennett

Personal Infomation


Presenter's Name

Andy Bennett

Degree Level

Undergraduate

Co-Authors

Steven Graves

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Steven Graves

Title

Gender Specific Lipid Biomarkers for Alzheimer\'s Disease

Abstract

Alzheimer’s Disease (AD) is a neurodegenerative disease that currently has no cure and diagnosis is subjective due to lack of reliable biomarkers. Early biochemical diagnose of AD would increase the effectiveness of drug trials before the disease is irreversible. In 2 indepentant studies, serum from AD cases and age matched controlls were collected. Lipids were extracted using organic solvents and then analyzed using direct infusion ESI-TOF MS. Spectra collected were then analyzed using peak height to determine abundance. From Study A, 87 molecules were identified as statically significant. In Study B, of those 87 markers, 35 continued to be significant. Reanalysis of the 35 biomarkers according to gender revealed that certain biomarkers are better able to distinguish  between AD cases and controls in men and other markers in women. Using these to create biomarker panels, these markers provided 91% sensitivity with 88% specificity for men and 94% sensitivity with 92% sensitivity for women. These studies are significant because they are among the first to identify gender specific lipid biomarkers for AD and suggest differeneces in the biochemsitry of AD in genders