Abstract by Eddie Lee
Chemistry and Biochemistry
Capillary Morphogenesis gene 2 mediates extracellular matrix uptake and targets it for degradation to maintain ECM homeostasis
Capillary morphogenesis gene protein 2 (CMG2) is a type I transmembrane-integrin-like receptor which is known to have a role in endocytosis of anthrax protective antigen (PA; a non-toxic moiety of the binary anthrax toxin). However, the understanding of the physiological role of CMG2 remains incomplete. Interestingly, mutations in CMG2 cause a disease called Hyaline Fibromatosis Syndrome (HFS) that is defined by the accumulation of hyaline material (extracellular matrix; ECM) in the skin, joints, bones and internal organs. This suggests that CMG2 has a role in mediating ECM uptake, and malfunction of CMG2 results in ECM accumulation. We want to investigate the phenotypic changes caused by CMG2 mutants compared to wildtype CMG2 in order to elucidate the physiological role of CMG2. We have evidence to show that 1. CMG2 mutants lose the function in endocytosis of ECM 2. malfunction of CMG2 could not localize at the cell surface which might be the caused for HFS disease and dysregulation of ECM homeostasis.