BYU

Abstract by Alexandra Thornock

Personal Infomation


Presenter's Name

Alexandra Thornock

Degree Level

Undergraduate

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Joshua Andersen

Title

LIMD1 and Atg9 Interaction in Autophagy

Abstract

Autophagy is a cell signaling pathway involved in chemo resistance that requires formation of autophagosome structures that gather cellular contents for lysosomal degradation. Atg9 is a central autophagy-promoting protein that transports structural membrane to autophagosomes for their expansion, and we have found that this translocation of Atg9 requires its interaction with the regulatory protein, 14-3-3. Our long-term objective is to fully understand the Atg9 pathway in autophagy. As our research has progressed, we have found that the scaffold protein, LIMD1, interacts with both Atg9 and 14-3-3 and thus may be involved in this pathway. We hypothesize that LIMD1 may regulate this 14-3-3 interaction with Atg9. This presentation will discuss data that supports this hypothesis and future experiments that will determine the role of LIMD1 in the Atg9 pathway of autophagy.