BYU

Abstract by Joshua Rasband

Personal Infomation


Presenter's Name

Joshua Rasband

Degree Level

Undergraduate

Co-Authors

Mark Transtrum

Abstract Infomation


Department

Physics and Astronomy

Faculty Advisor

Mark Transtrum

Title

Mapping the Behavior Space of the Hodgkin-Huxley Model

Abstract

The Hodgkin-Huxley model is a set of differential equations that describe electrical signals in neurons. In its simplest form, the model has twenty-five parameters, corresponding to physical properties such as membrane capacitance or ion conductances. The values of these parameters vary depending on physical or chemical conditions. Neurons exhibit a variety of behaviors depending on the parameter values. We explore the behavior space of the Hodgkin-Huxley model. We used model reduction techniques to remove irrelevant parameters, i.e., those that are unnecessary to explain a behavior. We now ask whether the reduced models can accurately mimic behaviors exhibited by the full model. We find that different neural behaviors are explained by different reduced models. By collecting these simplified models, we begin to map out the behavior space accessible by real neurons.