Abstract by Seth LeCates
Chemistry and Biochemistry
Q-Beta particle and adjuvant conjugant.
Staphylococci aureus in the last few decades has brought significant resistance to existing antibiotics, which is threatening millions of lives globally. The increasing alarm has prompted many scientists and researchers to explore new and creative strategies to deal with this deteriorating situation.
Our central hypothesis is that a virus-like particle with both short glycans and a glycolipid on its surface will overcome the limitations inherent in T-cell dependent immunological responses. Thus, providing a better combatant to Staphylococci aureus.
My goal is to synthesize a glycolipid adjuvant and conjugate it to a viral particle that contains a short polysaccharide chain.