Abstract by Hsien-Jung Lin
Chemistry and Biochemistry
Using protein stability as a matric of protein quality in protein homeostasis
The lifespan of US population has been increased from 45 in 1913 to 77 in 2015. People lives longer, in the same time age-related disease, such as cancer, and Alzheimer’s disease, also becomes more common. Slowing down the onset of these diseases may be accomplished by understanding the biochemical mechanisms of aging. It has been thought that aging is related to the decline of proteostasis, which is the decline of the functional balance in proteome. However, what contributes to the proteostasis decline remains unclear. We are creating a system scale model of proteostasis which includes synthesis, folding, and degradation, together to describe the phenomenon of proteostasis. The model we propose utilizes protein concentration, turnover rate and stability to understand how protein population and quality has changed overtime and between different condition. The literature and our preliminary data with mouse models suggests that during slow aging, the protein turnover slows down and the protein stability decreases. Here we investigate how this change in proteome scale turnover affects protein quality.