Abstract by Andrew Atoa
Chemistry and Biochemistry
Efficacy of CSAs in Wound Treatments Against Hypochlorous Acid Solutions
Many antibacterial wound treatments have led to drug resistance in microorganisms. Ceregenins (CSAs), antimicrobial peptide mimics derived from bile salts, have shown efficacy against drug-resistant bacteria and fungi, including Gram-negative and positive bacteria. CSA hydrogels and aqueous formulations were tested against several strains of drug-resistant microbes and compared with hypochlorous acid wound treatments to measure the speed and duration of the antimicrobial activity. Results show that CSA solutions are faster and longer-lasting (i.e. repeated inoculations) against Staphylococcus aureus (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Candida aureus (fungi) than current wound treatments containing hypochlorous acid.
Keywords: ceregenins, antimicrobial peptides, drug-resistant bacteria, drug-resistant fungi