Abstract by Thomas Knapp
Chemistry and Biochemistry
Efficacy of Ceragenin Cationic Steroid Antibiotic Coated Surgical Pins
Surgical pins, like many other medical devices that are implanted into patients for long periods of time are susceptible to infection and colonization by bacteria and fungi. Infections due to these micro-organisms are dangerous in that they can spread to the blood stream, infect vital organs and cause death to patients. Another issue that arises with medical device infections, is that many of the colonizing microbes are resistant to antibiotics typically used to combat these infections. Ceragenin Cationic Steroid Antibiotics (CSA's) have proven as effective antibiotics against both gram-positive and gram-negative bacteria as well as fungi and thus make a plausible candidate for protecting medical devices, specifically surgical pins, from infection. We chose to coat surgical pins with a PLGA-CSA 131 coating to test the efficacy of these coatings against MRSA. The results of our study showed that the CSA coated pins were effective in inhibiting microbial growth for 4 days after innoculation. Our research shows that CSA coatings are succesful in preventing unwanted colonization on surgical devices and should be further studied in other applications.